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What is a Lyme Disease Antibody Test and Why Is It Done?

A Lyme disease test is a specialized blood test used to detect the presence of antibodies or DNA fragments of the bacterium Borrelia burgdorferi, the bacteria that causes Lyme disease. This tick-borne illness can cause a range of symptoms, from mild flu-like conditions to serious complications affecting the heart, joints, and nervous system. Early Lyme disease symptoms often include fever, fatigue, joint pain, and a hallmark skin rash called erythema migrans. If you suspect a tick bite or you experience symptoms weeks after being outdoors in wooded or grassy areas, getting a Lyme disease antibody test near you is crucial. The test typically begins with an enzyme-linked immunosorbent assay (ELISA), and if results are positive or unclear, a follow-up Western blot test confirms the diagnosis. Early detection is essential to begin antibiotics and prevent long-term Lyme complications.

Who Should Get Tested for Lyme Disease?

Anyone who has been exposed to ticks in areas where Lyme disease is common should consider a Lyme disease screening. This includes individuals who live in or travel to regions known for tick populations, particularly the Northeast, Midwest, and parts of California. You should also get a Lyme disease test if you’ve recently noticed a bull's-eye-shaped rash, unexplained joint swelling, flu-like symptoms, or neurological issues like facial paralysis. Pregnant individuals, outdoor workers, hikers, and children who spend time in tick-infested environments are also at higher risk. If you search for “Lyme disease test after tick bite” or “symptoms of Lyme disease in pregnancy,” this diagnostic test can offer clarity and timely intervention.

When Is the Right Time to Take a Lyme Disease Test?

Timing is key when it comes to Lyme disease testing. Testing too early—within the first week of infection—might not produce accurate results because your body has not yet developed detectable antibodies. Most doctors recommend taking the test two to four weeks after the tick bite or the appearance of early symptoms. If you’ve developed neurological or cardiac symptoms weeks after exposure, testing is still advised, as the disease may have spread. Patients often ask, “How soon after a tick bite can I get tested for Lyme disease?” The answer depends on your symptoms, but in general, schedule a Lyme disease blood test if symptoms persist or worsen within a few weeks.

What Happens During the Lyme Disease Test Procedure?

The Lyme disease blood test is a simple outpatient procedure. A medical professional will draw a small blood sample from your arm, usually taking only about 10 to 15 minutes. No fasting or special preparation is needed before the test, although it’s helpful to stay hydrated and wear loose clothing for easy access to your arm. Once collected, the sample is sent to a lab where it is analyzed using the ELISA method. If the initial test is positive or borderline, a second test called the Western blot is performed to confirm the diagnosis. The total turnaround time for Lyme disease test results is typically 3 to 7 business days. You can easily book this test through LabFinder if you are looking for a “Lyme disease test with insurance near me.”

Can a Lyme Disease Test Help Detect Other Tick-Borne Illnesses?

While the standard Lyme disease test focuses on detecting Borrelia burgdorferi, it can be useful in ruling out or prompting further tests for co-infections. Ticks can carry multiple pathogens, and people infected with Lyme disease may also contract babesiosis, anaplasmosis, or ehrlichiosis. If your symptoms are severe or don’t fully match classic Lyme disease, your provider might recommend PCR testing or additional blood work to look for co-infections. A single tick bite blood panel may include screening for multiple pathogens, particularly for patients reporting neurological symptoms or persistent fever. If you’re searching for “tick fever blood test near me” or “multi-pathogen tick bite panel,” consult your healthcare provider about comprehensive testing.

Is the Lyme Disease Test Safe and Accurate?

The Lyme disease test is very safe with minimal risks. The most common side effects include minor pain, swelling, or bruising at the blood draw site. False positives and false negatives can occur, especially if the test is done too early. For best results, the two-tiered testing approach—ELISA followed by Western blot—is recommended. Advanced options like PCR tests or cerebrospinal fluid analysis may be used for diagnosing late-stage or neurological Lyme disease. If you’re looking for a “reliable Lyme disease test near me” or “accurate tick bite blood test,” be sure to book through trusted labs or platforms like LabFinder that partner with certified diagnostic centers.

How Do I Prepare for a Lyme Disease Test?

No fasting is required for a Lyme disease test. You can eat and drink normally before your appointment. It’s best to inform your provider about any recent antibiotics, steroids, or supplements, as these may affect your immune response and possibly alter results. Stay hydrated and wear a short-sleeved shirt or sleeves that can easily roll up to make the process more comfortable. If you’ve had Lyme disease before, or recently underwent another antibody test, bring those results for comparison. If you’ve been searching “how to prepare for Lyme test” or “Lyme disease test tips,” just know the process is easy and stress-free.

What Should I Do After Receiving My Lyme Disease Test Results?

If your test is positive, your doctor will most likely prescribe a course of antibiotics, often doxycycline or amoxicillin, depending on your age and health condition. Most early cases respond well to treatment. If the disease has progressed to the nervous or cardiac systems, you may need a longer course or intravenous antibiotics. If you receive a negative result but still experience symptoms, especially joint or nerve pain, follow up with your doctor for additional testing or imaging. If you’re wondering “what to do after Lyme disease diagnosis,” early action and consistent monitoring are key to full recovery.

Where Can I Book a Lyme Disease Test Near Me?

You can book a Lyme disease antibody test through LabFinder, which allows you to search and schedule an appointment with clinics near your zip code. Many locations offer same-day or next-day appointments and accept a variety of insurance plans. If you’re looking for “Lyme disease blood test near me with insurance” or “find a clinic for Lyme disease screening,” LabFinder is a convenient and secure way to locate certified testing centers in your area.

Conclusion

Lyme disease is a serious but treatable illness that can cause lasting damage if left undiagnosed. A Lyme disease test helps detect antibodies or bacterial DNA in your blood and guides your physician in starting timely treatment. Whether you were recently bitten by a tick, developed strange symptoms, or want peace of mind before symptoms appear, booking a Lyme disease test is a smart and proactive choice. You can find nearby clinics, compare costs, and book a tick bite blood test with insurance through trusted platforms like LabFinder. Don’t delay—take control of your health and schedule your Lyme disease test today.

When To Test

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Medically Reviewed by Dr. Robert Segal, MD, FACC

Reviewed by: Dr. Robert Segal, MD, FACC

Board-Certified Physician

Last Updated: August 20, 2025

The information on this page and throughout the LabFinder website and mobile app is for general informational purposes only. It is not intended to serve as medical advice, diagnosis, or treatment. For personalized medical advice or specific health concerns, please consult your healthcare provider directly.

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Frequently Asked Questions

  • How accurate is a Lyme disease blood test?

    The accuracy of a Lyme disease test depends on the stage of infection and the type of test used. The two-tier testing method recommended by the CDC—starting with an ELISA followed by a confirmatory Western blot—is considered highly accurate. However, false negatives can occur if the test is taken too soon after exposure, before the body has produced detectable antibodies.

  • How soon after a tick bite should I get tested for Lyme disease?

    Testing is usually most accurate 2 to 4 weeks after a tick bite, when your body has had time to develop antibodies. If symptoms like a bull's-eye rash, fatigue, or joint pain appear, consult a doctor immediately. Early testing may not always detect antibodies, so a follow-up test might be necessary if done too soon.

  • Can I take a Lyme disease test if I don’t have symptoms?

    Yes, you can get tested for Lyme disease even without symptoms, especially if you've recently been in a tick-infested area or removed a tick from your body. Preventive testing is often requested by those who are unsure of exposure but want peace of mind or early detection. Always consult your provider for the best time to test.

  • Where can I find a Lyme disease test near me that accepts insurance?

    You can book a Lyme disease test near you through platforms like LabFinder, which allow you to choose from nearby diagnostic labs and imaging centers. Many of these facilities accept insurance, helping you avoid high out-of-pocket costs. Use your zip code to search for options with same-day availability or weekend hours.

  • Is the Lyme disease test covered by insurance?

    Most health insurance plans cover Lyme disease testing, especially when symptoms are present or you've had a known tick bite. Coverage may depend on your provider and the lab you choose. To avoid surprise billing, it’s best to verify with the lab or use platforms that list in-network options for Lyme testing with insurance.

  • What should I do if my Lyme disease test result is positive?

    If you receive a positive Lyme disease test result, your doctor will likely prescribe antibiotics such as doxycycline or amoxicillin to eliminate the infection. Early treatment is highly effective and can prevent long-term health issues. Your provider may also order additional tests to check for complications or co-infections from the tick bite.

  • Can I book a Lyme Disease Test near me?

    Booking a Lyme Disease Test is easy using LabFinder. Just choose your location and enter your insurance information to find the closest Lyme Disease Test near you.

  • How can I make a same-day appointment for a Lyme Disease Test?

    To make a same day appointment for a Lyme Disease Test, just choose your location and your insurance information to find the closest Lyme Disease Test location near you. If there's availability for a same-day appointment at a nearby lab location, then you will be able to book it easily through LabFinder.

  • Where can I schedule a Lyme Disease Test?

    LabFinder allows you to easily schedule a Lyme Disease Test. You can search by location and insurance to easily book a Lyme Disease Test near you.

  • Can I make an appointment for Lyme Disease Test online?

    LabFinder allows you to easily make an appointment for a Lyme Disease Test online. To make an appointment for a Lyme Disease Test online, just choose your location and your insurance information to find the closest Lyme Disease Test near you.

  • Can I get a Lyme Disease Test without insurance?

    Yes, you can get a Lyme Disease Test without insurance. LabFinder allows you to search and select "Self-Pay" when booking a Lyme Disease Test. While pricing for the test may not be immediately available, please check by calling the lab company directly for pricing.

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