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What is the Plasma Metanephrines Test?

The Plasma Metanephrines Test, also known as the Plasma Free Metanephrines Test, is a diagnostic blood test used to detect elevated levels of metanephrines in the plasma. Metanephrines are metabolites of catecholamines, such as adrenaline and noradrenaline, which are produced by the adrenal glands. The test is highly sensitive and is primarily used to diagnose pheochromocytomas, which are rare tumors of the adrenal glands that secrete excess catecholamines. Additionally, the test can help in diagnosing paragangliomas, tumors that occur outside the adrenal glands. By measuring the levels of free metanephrines in the blood, this test aids healthcare providers in identifying these tumors, which can lead to high blood pressure, headaches, and other symptoms when left untreated.

Who can take the Plasma Metanephrines Test?

The Plasma Metanephrines Test is typically recommended for individuals who exhibit symptoms suggestive of pheochromocytomas or paragangliomas, including severe hypertension, headaches, sweating, palpitations, or unexplained anxiety. It is particularly useful for patients who have had high blood pressure that is difficult to control with medication. People who have a family history of adrenal tumors, certain genetic conditions like multiple endocrine neoplasia type 2 (MEN2), or who are at higher risk due to other factors, may also be candidates for the test. Additionally, this test is used for those who need to monitor the progress of a previously diagnosed tumor or check for recurrence after treatment.

When Can the Plasma Metanephrines Test Be Performed?

The Plasma Metanephrines Test can be performed whenever a healthcare provider suspects the presence of a pheochromocytoma or paraganglioma based on symptoms or other diagnostic findings. It is often conducted when a patient presents with symptoms such as uncontrolled high blood pressure, episodic headaches, sweating, or palpitations. This test is particularly useful if a patient has a history of abnormal blood pressure readings or other signs that may point to an adrenal tumor. It is commonly performed after imaging studies such as CT scans or MRIs suggest the presence of a tumor, or when a healthcare provider is looking to confirm the diagnosis before proceeding with further treatment or surgery.

Procedure and Duration

The Plasma Metanephrines Test involves drawing a blood sample, typically from a vein in the arm. The procedure is quick, usually taking only a few minutes. The sample is then sent to a laboratory where the levels of metanephrines are measured. It is important to note that the test may need to be timed according to certain conditions, as the levels of metanephrines can fluctuate throughout the day. In some cases, patients may be asked to prepare by avoiding certain foods, medications, or physical activities that could interfere with the results. After the blood draw, patients can immediately return to their normal activities. Results are typically available within a few days, depending on the laboratory's processing time.

Related Conditions or Illnesses

The Plasma Metanephrines Test is primarily used to detect pheochromocytomas and paragangliomas, two types of tumors that cause an overproduction of catecholamines. Pheochromocytomas are rare, usually benign tumors that form in the adrenal glands, while paragangliomas occur outside the adrenal glands but in areas where nerve tissue is present. Both tumors can cause symptoms like high blood pressure, headaches, excessive sweating, and rapid heart rate. The test is also related to conditions like hypertension that is difficult to control, particularly if the cause is suspected to be a catecholamine-secreting tumor. In addition to detecting these tumors, the Plasma Metanephrines Test can help in the monitoring and management of these conditions after diagnosis and treatment.

Risks

The Plasma Metanephrines Test is a low-risk procedure, as it involves only a routine blood draw. The most common risks associated with blood draws include slight pain or discomfort at the puncture site, mild bruising, or minor bleeding. In rare cases, individuals may experience dizziness or fainting. These symptoms are typically short-lived and resolve once the patient has rested. If the patient is having the test performed following a suspected pheochromocytoma or paraganglioma, the healthcare provider may be cautious about blood pressure spikes, as high catecholamine levels can cause a temporary increase in blood pressure. However, with proper preparation and monitoring, the test is considered very safe and is an important tool for diagnosing adrenal-related conditions.

Preparations

Before taking the Plasma Metanephrines Test, there are some preparatory steps patients may need to follow. It is recommended that patients avoid consuming caffeine, alcohol, or smoking for at least 12 hours prior to the test, as these substances can affect catecholamine levels and influence the results. Certain medications, especially those that impact blood pressure or nervous system function, may need to be paused before the test, but this should only be done under the guidance of a healthcare provider. In some cases, patients may be asked to avoid physical exertion or stress for a few hours before the test to prevent interference with the results. Following these instructions carefully will help ensure the most accurate and reliable test outcomes.

Other Similar Tests

Other tests that may be related to or used alongside the Plasma Metanephrines Test include urine metanephrine tests, which measure metanephrines in a 24-hour urine sample, and imaging tests like CT scans or MRIs, which can help visualize adrenal tumors or other abnormalities. The urine metanephrine test is often used as a screening tool for pheochromocytomas and paragangliomas, while imaging tests can confirm the location and size of the tumor. Additionally, genetic testing may be recommended for patients with a family history of pheochromocytomas, as genetic conditions like multiple endocrine neoplasia (MEN) can increase the likelihood of developing these tumors. These tests work together to provide a comprehensive view of a patient’s condition and guide treatment decisions.

Book Plasma Metanephrines Test Using LabFinder

LabFinder makes it easy to book the Plasma Metanephrines Test near your location. With participating labs and imaging centers, you can conveniently schedule your test online. These labs and centers often accept insurance, ensuring an accessible and affordable experience. So, if you're looking for a "Plasma Metanephrines test near me," "Catecholamine test near me," or "adrenal tumor test near me," you've come to the right place. LabFinder connects you with trusted labs, providing reliable diagnostic services for your healthcare needs.

Conclusion

The Plasma Metanephrines Test is an essential diagnostic tool for detecting pheochromocytomas and paragangliomas, which are rare tumors that can lead to high blood pressure and other serious symptoms. By measuring the levels of metanephrines in the blood, this test helps healthcare providers identify the presence of these tumors and make informed decisions about treatment. With LabFinder, you can easily book the Plasma Metanephrines Test at participating labs and imaging centers near you, many of which accept insurance. Take control of your health today by scheduling your test with LabFinder for a convenient and reliable diagnostic experience.


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Medically Reviewed by Dr. Robert Segal, MD, FACC

Reviewed by: Dr. Robert Segal, MD, FACC

Board-Certified Physician

Last Updated: November 20, 2025

The information on this page and throughout the LabFinder website and mobile app is for general informational purposes only. It is not intended to serve as medical advice, diagnosis, or treatment. For personalized medical advice or specific health concerns, please consult your healthcare provider directly.

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Frequently Asked Questions

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    Yes, you can get a Plasma Metanephrines Test without insurance. LabFinder allows you to search and select "Self-Pay" when booking a Plasma Metanephrines Test. While pricing for the test may not be immediately available, please check by calling the lab company directly for pricing.

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